Use these sites to help you make a difference:

These sites are mainly for South African users:

http://www.greatergoodsa.co.za/ – great for volunteering and donating to all registered associations in SA.
http://www.bbbssa.org.za/ – Big Brother / Big Sister SA because all children need guidance.
www.doj.gov.za/trc - Truth and reconciliation Commission SA.

And these are the ones that should and can be visted by all:

http://www.goodgifts.org/goodgifts/default.php - donations and gifts.
http://www.hrw.org/ - Human rights watch.
http://www.pledgebank.com/ - tell the world you will do it, if someone does it with you. A wonderful way to get communities involved.
http://www.worldonfire.ca/ - Sarah McLahlan was at a loss for how to shoot the music video for her song WORLD ON FIRE. It costs around $150 000 to make a music video. She spent $15 on the music video and donated the rest to various places all over the world that needed it. In conjunction with the GOODGIFTS site, you can help in small ways to.
http://www.unhchr.ch/udhr/ - a universal declaration of human rights as presented by the UN